IPITA-IXA-CTRMS 2023

05:30-06:25

05:30
Indigo 204

Indigo 204

Pre-clinical application of xenotransplantation

Takayuki Yamamoto, United States
What further steps are required to enable the successful clinical transfusion of pig red blood cells? Experience in the TKO pig-to-capuchin monkey model

Ralf R Tönjes, Germany
Isolation and functional analysis of an ecotropic porcine endogenous retrovirus PERV-C from a Yucatan SLA D/D haplotype inbred miniature swine

Cullen Soares, United States
Correlation of LV-Global Longitudinal Strain with Invasive Hemodynamics in the First Genetically Modified Porcine to Human Xeno Transplant

Christopher McGregor, United States
Gal knockout sheep: a new paradigm for future preclinical biological heart valve testing.

Julia Radan, Germany
Quantitative and qualitative assessment of pleural effusions after preclinical orthotopic cardiac xenotransplantation

05:30-06:25

05:30
Indigo D

Indigo D

Cellular transplantation

Time	Room	Session
05:30 - 06:25 \| Oral Abstract Sessions
05:30-06:25	05:30 Indigo 204	Indigo 204	Pre-clinical application of xenotransplantation Full Details Takayuki Yamamoto, United States What further steps are required to enable the successful clinical transfusion of pig red blood cells? Experience in the TKO pig-to-capuchin monkey model Takayuki Yamamoto, United States What further steps are required to enable the successful clinical transfusion of pig red blood cells? Experience in the TKO pig-to-capuchin monkey model Ralf R Tönjes, Germany Isolation and functional analysis of an ecotropic porcine endogenous retrovirus PERV-C from a Yucatan SLA D/D haplotype inbred miniature swine Ralf R Tönjes, Germany Isolation and functional analysis of an ecotropic porcine endogenous retrovirus PERV-C from a Yucatan SLA D/D haplotype inbred miniature swine Cullen Soares, United States Correlation of LV-Global Longitudinal Strain with Invasive Hemodynamics in the First Genetically Modified Porcine to Human Xeno Transplant Cullen Soares, United States Correlation of LV-Global Longitudinal Strain with Invasive Hemodynamics in the First Genetically Modified Porcine to Human Xeno Transplant Christopher McGregor, United States Gal knockout sheep: a new paradigm for future preclinical biological heart valve testing. Christopher McGregor, United States Gal knockout sheep: a new paradigm for future preclinical biological heart valve testing. Julia Radan, Germany Quantitative and qualitative assessment of pleural effusions after preclinical orthotopic cardiac xenotransplantation Julia Radan, Germany Quantitative and qualitative assessment of pleural effusions after preclinical orthotopic cardiac xenotransplantation
05:30-06:25	05:30 Indigo D	Indigo D	Cellular transplantation Full Details Roberto Gramignoli, Sweden 30 years of Human Hepatocyte Isolation and Cryogenic Preservation Roberto Gramignoli, Sweden 30 years of Human Hepatocyte Isolation and Cryogenic Preservation Balamurugan N. Appakalai, United States Beneficial effects of microvascular fragments and stromal vascular fraction cells collected from human peripancreatic fat for stimulating intra-islet endothelial cells to form peri-islet vessels in human islets during co-culture and co-transplantation. Balamurugan N. Appakalai, United States Beneficial effects of microvascular fragments and stromal vascular fraction cells collected from human peripancreatic fat for stimulating intra-islet endothelial cells to form peri-islet vessels in human islets during co-culture and co-transplantation.
06:00 - 07:30 \| Concurrent Sessions
06:00-07:30	06:00 Indigo A	Indigo A	Beta cell replacement towards standard of care (Joint) Full Details Angelika C. Gruessner, United States Short update on the data of the international registry of PTX Angelika C. Gruessner, United States Short update on the data of the international registry of PTX Raja Kandaswamy, United States Pancreas Transplantation Raja Kandaswamy, United States Pancreas Transplantation Eelco de Koning, Netherlands Allo-islet transplantation Eelco de Koning, Netherlands Allo-islet transplantation Rita Bottino, United States Xeno-islet transplantation Rita Bottino, United States Xeno-islet transplantation Maria Cristina Nostro, Canada Stem cell islet transplantation Maria Cristina Nostro, Canada Stem cell islet transplantation
06:30-07:30	06:30 Indigo 204	Indigo 204	Immunosuppression for Xenotransplantation (IXA) Full Details Andrew B. Adams, United States Nonclinical, novel immunosuppression and FDA Andrew B. Adams, United States Nonclinical, novel immunosuppression and FDA Robert A Montgomery, United States Clinically relevant immunosuppression Robert A Montgomery, United States Clinically relevant immunosuppression Martin Bender, Germany Controlling inflammation and coagulation Martin Bender, Germany Controlling inflammation and coagulation
06:30-07:30	06:30 Indigo D	Indigo D	Perinatal cells and tissues for regenerative medicine applications (CTRMS) Supported by: Full Details Roberto Gramignoli, Sweden Perinatal stem cells and tissues with multimodal functions for regenerative medicine applications Roberto Gramignoli, Sweden Perinatal stem cells and tissues with multimodal functions for regenerative medicine applications Toshio Miki, Japan Unlocking the Potential of Amniotic Epithelial Cells: Past Achievements and Future Prospects Toshio Miki, Japan Unlocking the Potential of Amniotic Epithelial Cells: Past Achievements and Future Prospects David Lott, United States Human amniotic epithelial cell transplantation improves scar remodeling in a rabbit model of acute vocal fold injury: a pilot study David Lott, United States Human amniotic epithelial cell transplantation improves scar remodeling in a rabbit model of acute vocal fold injury: a pilot study
06:30-07:30	06:30 Indigo H	Indigo H	Machine Perfusion: Expanding the donor pool (IPITA) Full Details Chris Callaghan, United Kingdom Utilizing DCD donors for pancreas, islet cell transplant Chris Callaghan, United Kingdom Utilizing DCD donors for pancreas, islet cell transplant Dianne McKay, United States Using machine perfusion to optimize marginal donors Dianne McKay, United States Using machine perfusion to optimize marginal donors James A. Richards, United Kingdom Normothermic regional perfusion James A. Richards, United Kingdom Normothermic regional perfusion
07:30 - 08:00 \| Coffee Break and Exhibit Area
07:30-08:00	07:30 Foyer Area	Foyer Area	Coffee Break Full Details
08:00 - 09:30 \| Oral Abstract Sessions
08:00-09:30	08:00 Indigo A	Indigo A	Islet transplantation: Extending islet donation and islet transplant "Potpouri" Full Details Rutger M van Rooden, Netherlands Improved pancreatic islet isolation yield after abdominal normothermic regional perfusion of controlled donation after circulatory death donors Rutger M van Rooden, Netherlands Improved pancreatic islet isolation yield after abdominal normothermic regional perfusion of controlled donation after circulatory death donors Alan P Timpson, United Kingdom Islet Isolations From Extended Criteria Donors Alan P Timpson, United Kingdom Islet Isolations From Extended Criteria Donors Takayuki Anazawa, Japan Islet Transplantation using Donors After Brain and Cardiac Death: A Multicenter Clinical Trial in Japan Takayuki Anazawa, Japan Islet Transplantation using Donors After Brain and Cardiac Death: A Multicenter Clinical Trial in Japan Jared MR Firth, United Kingdom Developing an algorithm for islet transplant dosing that considers both pancreas donor and islet recipient factors Jared MR Firth, United Kingdom Developing an algorithm for islet transplant dosing that considers both pancreas donor and islet recipient factors Kenneth Nicoll, United Kingdom 10-year experience of Donors after Circulatory Death for Islet Transplantation in Scotland Kenneth Nicoll, United Kingdom 10-year experience of Donors after Circulatory Death for Islet Transplantation in Scotland Gumpei Yoshimatsu, Japan Analysis of islet isolation from DCD for allogeneic human islet transplantation to type1 diabetes – single center experience. Gumpei Yoshimatsu, Japan Analysis of islet isolation from DCD for allogeneic human islet transplantation to type1 diabetes – single center experience. Anjali Verma, United States Single nucleotide polymorphisms associated with human islet insulin secretion Anjali Verma, United States Single nucleotide polymorphisms associated with human islet insulin secretion Siri Larsen, United States Naturally purified islets in total pancreatectomy (TP) and islet autotransplant (IAT) for chronic pancreatitis: a model to evaluate impact of exocrine co-transplant on graft function Siri Larsen, United States Naturally purified islets in total pancreatectomy (TP) and islet autotransplant (IAT) for chronic pancreatitis: a model to evaluate impact of exocrine co-transplant on graft function Hiroyuki Kato, United States Hypoxia-related genes in pre-transplant human islets as potential markers for the transplantation outcomes in diabetic mice Hiroyuki Kato, United States Hypoxia-related genes in pre-transplant human islets as potential markers for the transplantation outcomes in diabetic mice
08:00-09:30	08:00 Indigo 204	Indigo 204	Immune monitoring for rejection / Immunomodulation / tolerance Full Details Farshid Fathi, United States Defining the human anti-pig xenoreactive T cell repertoire Farshid Fathi, United States Defining the human anti-pig xenoreactive T cell repertoire Soha Mcheik, United States Combined double thymus transplantation and mixed xenogeneic chimerism for the induction of optimal tolerance and enhancement of immune function Soha Mcheik, United States Combined double thymus transplantation and mixed xenogeneic chimerism for the induction of optimal tolerance and enhancement of immune function Chung Young Kim, Korea Proteomic Pathways in Rejected Grafts of Pig-to-Rhesus Corneal Xenotransplantation Chung Young Kim, Korea Proteomic Pathways in Rejected Grafts of Pig-to-Rhesus Corneal Xenotransplantation Jordan M Wong, Canada Exploring local immune modulation with rapamycin-eluting microparticles to preserve islet graft function in mice Jordan M Wong, Canada Exploring local immune modulation with rapamycin-eluting microparticles to preserve islet graft function in mice Daniel H Wolbrom, United States Long term survival (>365 days) of swine to baboon thymokidney transplant from alpha1,3-galactosyltransferase gene-knockout donors Daniel H Wolbrom, United States Long term survival (>365 days) of swine to baboon thymokidney transplant from alpha1,3-galactosyltransferase gene-knockout donors Takaaki Kobayashi, Japan Immunological challenges to control indirect recognition pathway for long-term outcome in xenotransplantation Takaaki Kobayashi, Japan Immunological challenges to control indirect recognition pathway for long-term outcome in xenotransplantation Joe Ladowski, United States A Histocompatibility Epitope Prediction Software for Xenotransplantation Donor-Recipient Optimization Joe Ladowski, United States A Histocompatibility Epitope Prediction Software for Xenotransplantation Donor-Recipient Optimization Man Zhang, People's Republic of China Swine leukocyte antigen (SLA) induces significant antibody production after pig-to-rhesus monkey kidney xenotransplantation Man Zhang, People's Republic of China Swine leukocyte antigen (SLA) induces significant antibody production after pig-to-rhesus monkey kidney xenotransplantation
08:00-09:30	08:00 Indigo D	Indigo D	Pre-clinical and clinical application of xenotransplantation and current barriers 4 Full Details Gannon McGrath, United States Ischemia minimization is associated with improved cardiac function in an ex vivo xeno working heart model Gannon McGrath, United States Ischemia minimization is associated with improved cardiac function in an ex vivo xeno working heart model Harvey Pass, United States Immunotranscriptomic Changes During Two Pig-to-Human Kidney Xenotransplantation Cases Harvey Pass, United States Immunotranscriptomic Changes During Two Pig-to-Human Kidney Xenotransplantation Cases Antonia W. Godehardt, Germany PCR and peptide based PCMV detection in pig - development and application of a combined testing procedure differentiating newly from latent infected pigs Antonia W. Godehardt, Germany PCR and peptide based PCMV detection in pig - development and application of a combined testing procedure differentiating newly from latent infected pigs Songzhe He, People's Republic of China Incidence of serum antibodies to xenoantigens on triple-knockout pig cells in different human groups Songzhe He, People's Republic of China Incidence of serum antibodies to xenoantigens on triple-knockout pig cells in different human groups Ikechukwu S Ileka, United States Pilot Evaluation of a Clinical Xeno Heart Transplant Regimen in a Preclinical Model Ikechukwu S Ileka, United States Pilot Evaluation of a Clinical Xeno Heart Transplant Regimen in a Preclinical Model Ikechukwu S Ileka, United States Extended Survival of 9- and 10-Gene-Edited Pig Heart Xenografts with Ischemia Minimization and CD154 Costimulation Blockade-Based Immunosuppression Ikechukwu S Ileka, United States Extended Survival of 9- and 10-Gene-Edited Pig Heart Xenografts with Ischemia Minimization and CD154 Costimulation Blockade-Based Immunosuppression Matthias Längin, Germany Hypertrophic hearts develop dynamic left ventricular outflow tract obstruction after orthotopic pig-to-baboon xenotransplantation Matthias Längin, Germany Hypertrophic hearts develop dynamic left ventricular outflow tract obstruction after orthotopic pig-to-baboon xenotransplantation Chace Mitchell, United States Preservation of Cardiac Xenografts in a Model of Infant Human Cardiac Xenotransplantation Chace Mitchell, United States Preservation of Cardiac Xenografts in a Model of Infant Human Cardiac Xenotransplantation Manjula G Ananthram, United States Clinical and prognostic value of echocardiography with global longitudinal strain in the first genetically modified porcine to human cardiac xenotransplant Manjula G Ananthram, United States Clinical and prognostic value of echocardiography with global longitudinal strain in the first genetically modified porcine to human cardiac xenotransplant
08:00-09:30	08:00 Indigo H	Indigo H	Pancreas Transplantation: Assessing outcomes and long-term results Full Details Diego Cantarovich, France A novel risk factor for immediate pancreas graft failure: hypertension in the donor. Diego Cantarovich, France A novel risk factor for immediate pancreas graft failure: hypertension in the donor. Angelika C. Gruessner, United States Solitary Pancreas Transplantation - Significant Improvement over the 2 last Decades Angelika C. Gruessner, United States Solitary Pancreas Transplantation - Significant Improvement over the 2 last Decades Angelika C. Gruessner, United States Long-Term survival and life-time benefit of pancreas transplantation Angelika C. Gruessner, United States Long-Term survival and life-time benefit of pancreas transplantation Audrey Brown, United States The Tissue Common Response Module (tCRM) score predicts treatment response for acute cellular rejection following pancreas transplant Audrey Brown, United States The Tissue Common Response Module (tCRM) score predicts treatment response for acute cellular rejection following pancreas transplant Samrat Ray, Canada Establishment of a genetic signature of ischemia reperfusion injury in a porcine pancreas transplantation model Samrat Ray, Canada Establishment of a genetic signature of ischemia reperfusion injury in a porcine pancreas transplantation model Ana Claudia Vidigal, Brazil Impact of C1q-fixing donor-specific antibodies on pancreas transplant outcomes Ana Claudia Vidigal, Brazil Impact of C1q-fixing donor-specific antibodies on pancreas transplant outcomes Ana Claudia Vidigal, Brazil Mean fluorescence intensity evolution is a more sensitive predictor than simple positivity of posttransplant donor-specific antibodies in pancreas transplantation outcomes Ana Claudia Vidigal, Brazil Mean fluorescence intensity evolution is a more sensitive predictor than simple positivity of posttransplant donor-specific antibodies in pancreas transplantation outcomes Pedro Ventura-Aguiar, Spain Peripheral blood mononuclear cells transcriptomic profile reveals a more prominent role of innate immune cells in pancreas rejection Pedro Ventura-Aguiar, Spain Peripheral blood mononuclear cells transcriptomic profile reveals a more prominent role of innate immune cells in pancreas rejection
09:35 - 10:35 \| Abstract Sessions
09:35-10:35	09:35 Indigo A	Indigo A	Oral Abstract Session: Ethics and Islet transplantation Full Details Daniel J Hurst, United States Risk to Research Non-Participants: Ethical Dimensions of Protecting Bystanders in Xenotransplantation Clinical Trials Daniel J Hurst, United States Risk to Research Non-Participants: Ethical Dimensions of Protecting Bystanders in Xenotransplantation Clinical Trials Martin Wijkstrom, United States Considerations for inclusion/exclusion criteria for clinical pig kidney xenotransplantation Martin Wijkstrom, United States Considerations for inclusion/exclusion criteria for clinical pig kidney xenotransplantation Andrea Baehr, Germany LEA29Y expression affects myocardial ischemia/reperfusion outcome in pigs Andrea Baehr, Germany LEA29Y expression affects myocardial ischemia/reperfusion outcome in pigs William Lin, United States Timing of anti-thymocyte globulin infusion affects islet engraftment after intraportal allotransplantation in patients with T1DM William Lin, United States Timing of anti-thymocyte globulin infusion affects islet engraftment after intraportal allotransplantation in patients with T1DM Jagan Kalivarathan, United States Surface modification of Bissulfosuccinimidyl suberate as an encapsulation strategy for islet transplants Jagan Kalivarathan, United States Surface modification of Bissulfosuccinimidyl suberate as an encapsulation strategy for islet transplants
09:35-10:35	09:35 Indigo 204	Indigo 204	Mini-Oral Abstract Session: Miscellaneous topics 3 Full Details Man Zhang, People's Republic of China Direct application of flow cytometry for the determination of porcine blood group antigens Man Zhang, People's Republic of China Direct application of flow cytometry for the determination of porcine blood group antigens Christopher J. Webb, United States Does dialysis modality or duration influence outcomes in simultaneous pancreas-kidney transplant recipients in the modern era? Christopher J. Webb, United States Does dialysis modality or duration influence outcomes in simultaneous pancreas-kidney transplant recipients in the modern era? Marcelo Perosa, Brazil Intraoperative versus postoperative administration of rabbit antithymocyte globulin in pancreas transplantation Marcelo Perosa, Brazil Intraoperative versus postoperative administration of rabbit antithymocyte globulin in pancreas transplantation Sarah Gondek, United States Pancreas after islet and islet after pancreas transplantation offer a durable insulin independence to patients with type 1 diabetes mellitus and problematic hypoglycemia. Sarah Gondek, United States Pancreas after islet and islet after pancreas transplantation offer a durable insulin independence to patients with type 1 diabetes mellitus and problematic hypoglycemia. Piotr Witkowski, United States Emerging data from a study of tegoprubart for the prevention of rejection in kidney transplant recipients: Implications for a similar study in islet cell transplantation Piotr Witkowski, United States Emerging data from a study of tegoprubart for the prevention of rejection in kidney transplant recipients: Implications for a similar study in islet cell transplantation Lauri Paasonen, Finland Nanofibrillated Cellulose Hydrogel with Stem Cells, Organoids and Wound Care Lauri Paasonen, Finland Nanofibrillated Cellulose Hydrogel with Stem Cells, Organoids and Wound Care Giuseppe Pettinato, United States Biophysical properties of hiPSC-derived pancreatic organoids Giuseppe Pettinato, United States Biophysical properties of hiPSC-derived pancreatic organoids Angeles Baquerizo, United States Analysis of human anti-porcine immune response in sensitized patients exposed to porcine hepatocytes Angeles Baquerizo, United States Analysis of human anti-porcine immune response in sensitized patients exposed to porcine hepatocytes
09:35-10:35	09:35 Indigo D	Indigo D	Mini-Oral Abstract Session: Miscellaneous topics 2 Full Details Karen Khalil, United States Perceptions and Potential Barriers of Personnel Involved in Xenotransplant Research Karen Khalil, United States Perceptions and Potential Barriers of Personnel Involved in Xenotransplant Research Oneib Khan, United States Repolarization/ST segment characteristics in serial 12-lead EKGS in the worldwide first genetically modified porcine-to human xenotransplant Oneib Khan, United States Repolarization/ST segment characteristics in serial 12-lead EKGS in the worldwide first genetically modified porcine-to human xenotransplant Oneib Khan, United States EKG appearance and evolution of baseline EKG-characteristics in the worldwide first genetically modified porcine-to-human xenotransplant (“pig heart-in-human body”) Oneib Khan, United States EKG appearance and evolution of baseline EKG-characteristics in the worldwide first genetically modified porcine-to-human xenotransplant (“pig heart-in-human body”) Rohan Bhattacharjya, Australia Demand Prevalence on Health Care Services by Type 1 and 2 Diabetes Mellitus in an Australian Population – a data linkage analysis Rohan Bhattacharjya, Australia Demand Prevalence on Health Care Services by Type 1 and 2 Diabetes Mellitus in an Australian Population – a data linkage analysis Antoine Buemi MD, Belgium Continuous vs Discontinuous Purification of Isolated Human Islets: Functional and Morphological Comparison Antoine Buemi MD, Belgium Continuous vs Discontinuous Purification of Isolated Human Islets: Functional and Morphological Comparison Emma Finegan, United States Critical Care Nursing Experience with Xenotransplant Research Emma Finegan, United States Critical Care Nursing Experience with Xenotransplant Research Samjhana Shrestha, Germany LEA29Y expression alleviates organ rejection in a porcine heterotopic abdominal heart transplantation model Samjhana Shrestha, Germany LEA29Y expression alleviates organ rejection in a porcine heterotopic abdominal heart transplantation model Juan A Gonzalez, Chile Salvage of a Thrombosed Pancreas Graft By Endovascular Thrombectomy. Juan A Gonzalez, Chile Salvage of a Thrombosed Pancreas Graft By Endovascular Thrombectomy.
09:35-10:35	09:35 Indigo H	Indigo H	Mini-Oral Abstract Session: Miscellaneous topics 1 Full Details Roberta Pisu, Italy Metabolomic and Lipidomic Profiling of the Amniotic Stromal Cell Secretome Roberta Pisu, Italy Metabolomic and Lipidomic Profiling of the Amniotic Stromal Cell Secretome Heiner Niemann, Germany Long term study of decellularized and glycan-modified GGTA1-KO porcine heart valves implanted into baboons Heiner Niemann, Germany Long term study of decellularized and glycan-modified GGTA1-KO porcine heart valves implanted into baboons Naoaki Sakata, Japan Thirty seven degrees Celsius is preferable temperature condition for long-term culture of porcine islets. Naoaki Sakata, Japan Thirty seven degrees Celsius is preferable temperature condition for long-term culture of porcine islets. Byung Joon Kim, Korea Clinical trial protocol for porcine islet xenotransplantation in South Korea Byung Joon Kim, Korea Clinical trial protocol for porcine islet xenotransplantation in South Korea Volkert Huurman, Netherlands Early graft loss in solitary pancreas transplant recipients within Eurotransplant Volkert Huurman, Netherlands Early graft loss in solitary pancreas transplant recipients within Eurotransplant
10:35 - 12:00 \| Lunch Break and Industry Symposium
10:35-12:00	10:35 Hilton lobby area	Hilton lobby area	Lunch Break Full Details
10:50-11:50	10:50 Indigo BC	Indigo BC	eGenesis Symposium on Allografts and Xenografts: Friends or Foes? Organized and Sponsored by: Full Details Stuart J Knechtle, United States Debate #1: Sensitized patients are at high risk for xenotransplantation - FOR Stuart J Knechtle, United States Debate #1: Sensitized patients are at high risk for xenotransplantation - FOR Massimo Mangiola, United States Debate #1: Sensitized patients are at high risk for xenotransplantation - AGAINST Massimo Mangiola, United States Debate #1: Sensitized patients are at high risk for xenotransplantation - AGAINST Alfred J. Tector, United States Debate #2: Recipients of xenograft are at higher risk for receiving subsequent allotransplantation - FOR Alfred J. Tector, United States Debate #2: Recipients of xenograft are at higher risk for receiving subsequent allotransplantation - FOR Leo Hans Buhler, Switzerland Debate #2: Recipients of xenograft are at higher risk for receiving subsequent allotransplantation - AGAINST Leo Hans Buhler, Switzerland Debate #2: Recipients of xenograft are at higher risk for receiving subsequent allotransplantation - AGAINST
12:00 - 13:30 \| Concurrents and Abstract Sessions
12:00-14:00	12:00 Indigo A	Indigo A	IXA Special Lecture / Business Meeting and Awards Full Details Wayne J Hawthorne, Australia Introduction to Keith Reemtsma Award Recipient Wayne J Hawthorne, Australia Introduction to Keith Reemtsma Award Recipient Chung-Gyu Park, Korea 2023 Keith Reemtsma Lecture Award on TBD Chung-Gyu Park, Korea 2023 Keith Reemtsma Lecture Award on TBD Wayne J Hawthorne, Australia Introduction to IXA Honorary Award Recipient Wayne J Hawthorne, Australia Introduction to IXA Honorary Award Recipient Richard N. Pierson III, United States 2023 IXA Honorary Lecture Award on TBD Richard N. Pierson III, United States 2023 IXA Honorary Lecture Award on TBD Wayne J Hawthorne, Australia Introduction to Agnes Azimzadeh Award Recipient Wayne J Hawthorne, Australia Introduction to Agnes Azimzadeh Award Recipient Linda Scobie, United Kingdom 2023 Agnes Azimzadeh Lecture Award on TBD Linda Scobie, United Kingdom 2023 Agnes Azimzadeh Lecture Award on TBD Wayne J Hawthorne, Australia David Cooper and Scientific Congress Awards Wayne J Hawthorne, Australia David Cooper and Scientific Congress Awards Wayne J Hawthorne, Australia IXA Business Meeting Wayne J Hawthorne, Australia IXA Business Meeting
12:00-13:30	12:00 Indigo 204	Indigo 204	Concurrent Session: Repeat pancreas transplant (IPITA) Full Details Caterina Di Bella, Italy Treatment Opinion 1: Pancreas Re-Transplantation / Junior Caterina Di Bella, Italy Treatment Opinion 1: Pancreas Re-Transplantation / Junior Daniel Doherty, United Kingdom Treatment Opinion 2: Re-Transplantatinon with Islets / Junior Daniel Doherty, United Kingdom Treatment Opinion 2: Re-Transplantatinon with Islets / Junior Shazli Azmi, United Kingdom Treatment Opinion 3: Closed Loop Pump Technology / Junior Shazli Azmi, United Kingdom Treatment Opinion 3: Closed Loop Pump Technology / Junior Jonathan Fridell, United States Treatment Opinion 1: Pancreas Re-Transplantation / Senior Jonathan Fridell, United States Treatment Opinion 1: Pancreas Re-Transplantation / Senior Michiel Nijhoff, Netherlands Treatment Opinion 2: Re-Transplantatinon with Islets / Senior Michiel Nijhoff, Netherlands Treatment Opinion 2: Re-Transplantatinon with Islets / Senior Michael R Rickels, United States Treatment Opinion 3: Closed Loop Pump Technology / Senior Michael R Rickels, United States Treatment Opinion 3: Closed Loop Pump Technology / Senior
12:00-13:30	12:00 Indigo D	Indigo D	Oral Abstract Session: Encapsulation of cellular transplants 1 Full Details Praveen Kumar Raju Pedabaliyarasimhuni, Canada Preliminary results on the survival and maturation of stem-cell derived beta cells at different stages in a novel immunoprotective double encapsulation device Praveen Kumar Raju Pedabaliyarasimhuni, Canada Preliminary results on the survival and maturation of stem-cell derived beta cells at different stages in a novel immunoprotective double encapsulation device David J Leishman, United States A bioengineered artificial interstitium supports long-term survival of therapeutic xenogeneic porcine islet cells in nonhuman primates without immunosuppression David J Leishman, United States A bioengineered artificial interstitium supports long-term survival of therapeutic xenogeneic porcine islet cells in nonhuman primates without immunosuppression Paul R.V. Johnson, United Kingdom An oxygen-delivering Hyaluronic acid-based matrix reduces inflammation and promotes human islet survival in macroencapsulation devices Paul R.V. Johnson, United Kingdom An oxygen-delivering Hyaluronic acid-based matrix reduces inflammation and promotes human islet survival in macroencapsulation devices Rosy Eloy, France How to deliver a therapeutic dose of encapsulated human islets? Rosy Eloy, France How to deliver a therapeutic dose of encapsulated human islets? Harald Stover, Canada Islet encapsulation preserves their functionality following transplantation into immunocompetent diabetic animals without immunosuppression. Harald Stover, Canada Islet encapsulation preserves their functionality following transplantation into immunocompetent diabetic animals without immunosuppression. Riccardo Calafiore, Italy Alginate-based (G) microcapsules (MC): a versatile tool for the experimental cell therapy and prevention of T1D Riccardo Calafiore, Italy Alginate-based (G) microcapsules (MC): a versatile tool for the experimental cell therapy and prevention of T1D Lina Mariana, Australia Survival and function of the adrenal cell in immunoisolation device in adrenalectomized mice and sheep. Lina Mariana, Australia Survival and function of the adrenal cell in immunoisolation device in adrenalectomized mice and sheep. Sara Photiadis, United States A novel endovascular bioartificial pancreas device to treat type 1 diabetes Sara Photiadis, United States A novel endovascular bioartificial pancreas device to treat type 1 diabetes Sawsen Bekir, France Development, optimization, and preclinical evaluation of a bio-artificial pancreas for the treatment of type 1 diabetes (T1D) Sawsen Bekir, France Development, optimization, and preclinical evaluation of a bio-artificial pancreas for the treatment of type 1 diabetes (T1D)
12:00-13:30	12:00 Indigo H	Indigo H	Concurrent Session: Enabling technologies (CTRMS) Full Details Benjamin Freedman, United States Interspecies blastocyst complementation: harnessing xeno, gene editing and iPS technologies to meet the organ demand Benjamin Freedman, United States Interspecies blastocyst complementation: harnessing xeno, gene editing and iPS technologies to meet the organ demand Giuseppe Orlando, United States Mitochondrial transfer to repair untransplantable organs and increase the donor pool Giuseppe Orlando, United States Mitochondrial transfer to repair untransplantable organs and increase the donor pool Klearchos K. Papas, United States Encapsulation and oxygen delivery Klearchos K. Papas, United States Encapsulation and oxygen delivery Sang Jin Lee, United States 3D printing complex organs Sang Jin Lee, United States 3D printing complex organs
13:30 - 14:00 \| Coffee Break
13:30-14:00	13:30 Foyer Area	Foyer Area	Coffee Break Full Details
14:00 - 15:30 \| Abstract Sessions / Young Investigator Workshop
14:00-15:30	14:00 Indigo A	Indigo A	Islet transplant: Clinical Studies in Islet Allo and Auto-Transplantation Full Details Bashoo Naziruddin, United States Total Pancreatectomy with Islet Autotransplantation- Single Center Outcome with Large Cohort of Patients Bashoo Naziruddin, United States Total Pancreatectomy with Islet Autotransplantation- Single Center Outcome with Large Cohort of Patients Denghao Wu, Australia The Epidemiology of Hereditary Pancreatitis in Australia and its effect on patient of Total Pancreatectomy with Islet Auto-Transplantation (TPIAT). Denghao Wu, Australia The Epidemiology of Hereditary Pancreatitis in Australia and its effect on patient of Total Pancreatectomy with Islet Auto-Transplantation (TPIAT). Aye Aye Thant, United Kingdom Relationship of diabetes technology use with prognosis in people with type 1 diabetes awaiting islet or simultaneous islet kidney transplantation Aye Aye Thant, United Kingdom Relationship of diabetes technology use with prognosis in people with type 1 diabetes awaiting islet or simultaneous islet kidney transplantation David A. Baidal, United States Islet-alone vs. islet-after-kidney transplantation glycemic outcomes: Report from the Collaborative Islet Transplant Registry David A. Baidal, United States Islet-alone vs. islet-after-kidney transplantation glycemic outcomes: Report from the Collaborative Islet Transplant Registry Mehdi Maanaoui, France Islet transplantation versus insulin alone in type 1 diabetic kidney transplant recipients: a French nationwide study on behalf of the TREPID group Mehdi Maanaoui, France Islet transplantation versus insulin alone in type 1 diabetic kidney transplant recipients: a French nationwide study on behalf of the TREPID group Michael R Rickels, United States Beta-cell function and insulin sensitivity with islet transplant alone and islet-after-kidney transplantation for type 1 diabetes in the Clinical Islet Transplantation (CIT) Consortium Michael R Rickels, United States Beta-cell function and insulin sensitivity with islet transplant alone and islet-after-kidney transplantation for type 1 diabetes in the Clinical Islet Transplantation (CIT) Consortium Braulio A Marfil-Garza, Canada BETA-2 scores overestimate graft function in pancreatic islet transplant recipients with an estimated glomerular filtration rate of <30 ml/min/1.73m2 Braulio A Marfil-Garza, Canada BETA-2 scores overestimate graft function in pancreatic islet transplant recipients with an estimated glomerular filtration rate of <30 ml/min/1.73m2 Shareen Forbes, United Kingdom Cost Savings Using The BETA-2 Versus Beta Score In Follow-Up Of Islet Transplant Recipients In The UK Islet Transplant Consortium. Shareen Forbes, United Kingdom Cost Savings Using The BETA-2 Versus Beta Score In Follow-Up Of Islet Transplant Recipients In The UK Islet Transplant Consortium. Piotr Witkowski, United States Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell-Derived, Fully Differentiated Islet Cells: Updated Data from the VX-880 Clinical Study Piotr Witkowski, United States Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell-Derived, Fully Differentiated Islet Cells: Updated Data from the VX-880 Clinical Study
14:00-15:30	14:00 Indigo 204	Indigo 204	Enabling technologies Full Details Roberto Gramignoli, Sweden Perfusion Bioreactor and Decellularized Liver Matrix in Support of Human Amnion Epithelial Cell Maturation into Functional Hepatocyte-like Cells Roberto Gramignoli, Sweden Perfusion Bioreactor and Decellularized Liver Matrix in Support of Human Amnion Epithelial Cell Maturation into Functional Hepatocyte-like Cells Anna Kulaga, Australia Development of a model to fabricate vascularised 3D bioprinted constructs to support islet transplantation for type 1 diabetes Anna Kulaga, Australia Development of a model to fabricate vascularised 3D bioprinted constructs to support islet transplantation for type 1 diabetes Jacqueline V. Schiesser, Australia Identification of novel cell surface markers for the characterization of human beta cell replacement therapies Jacqueline V. Schiesser, Australia Identification of novel cell surface markers for the characterization of human beta cell replacement therapies Martha Fowler, United States Gelatin methacrylate and polyethylene glycol diacrylate 3D printed hydrogels support vascularization for islet transplantation Martha Fowler, United States Gelatin methacrylate and polyethylene glycol diacrylate 3D printed hydrogels support vascularization for islet transplantation Juan Fernández, Germany Modifying The Porcine Genome for Xeno-organ Transplantation Juan Fernández, Germany Modifying The Porcine Genome for Xeno-organ Transplantation Brendan Keating, United States Integrative omic Profiling and Analyses in Two Pig Heart to Human Xenotransplants Brendan Keating, United States Integrative omic Profiling and Analyses in Two Pig Heart to Human Xenotransplants Nicol Gloddek, Germany [68Ga]Ga-DOTA-Exendin-4 PET/CT detects increased liver signal of transplanted neonatal islet cell clusters in diabetic pig recipients Nicol Gloddek, Germany [68Ga]Ga-DOTA-Exendin-4 PET/CT detects increased liver signal of transplanted neonatal islet cell clusters in diabetic pig recipients Mitra Gultom, Switzerland Glycocalyx dynamics of genetically modified arterial and venous porcine endothelial cells after xenogeneic activation Mitra Gultom, Switzerland Glycocalyx dynamics of genetically modified arterial and venous porcine endothelial cells after xenogeneic activation Alexander J Sagar, United Kingdom 48-hour normothermic xenoperfusion of genetically engineered porcine livers with whole human blood Alexander J Sagar, United Kingdom 48-hour normothermic xenoperfusion of genetically engineered porcine livers with whole human blood
14:00-15:30	14:00 Indigo D	Indigo D	Young Investigator Workshop on Career Development (Joint) Full Details Melena Bellin, United States Editor roundtable - Transplantation Melena Bellin, United States Editor roundtable - Transplantation Roberto Gramignoli, Sweden Organogenisis journal representative Roberto Gramignoli, Sweden Organogenisis journal representative Leo Hans Buhler, Switzerland Editor-in-chief round table - Xenotransplantation Leo Hans Buhler, Switzerland Editor-in-chief round table - Xenotransplantation Jaime A Giraldo, United States Grant funding - JDRF Jaime A Giraldo, United States Grant funding - JDRF Peter G. Stock, United States "Extracurricular" activities Peter G. Stock, United States "Extracurricular" activities Ty B. Dunn, United States Pursuing a surgical career Ty B. Dunn, United States Pursuing a surgical career Klearchos K. Papas, United States Basic Scientist career track Klearchos K. Papas, United States Basic Scientist career track Lorenzo Piemonti, Italy Basic Scientist career track Lorenzo Piemonti, Italy Basic Scientist career track Ekaterine Berishvili, Switzerland Developing an inclusion mindset and equity Ekaterine Berishvili, Switzerland Developing an inclusion mindset and equity Hanne Scholz, Norway Developing an inclusion mindset and equity Hanne Scholz, Norway Developing an inclusion mindset and equity Silke Niederhaus, United States Work / life balance Silke Niederhaus, United States Work / life balance Matt Tector, United States Academia vs industry Matt Tector, United States Academia vs industry
14:00-15:30	14:00 Indigo H	Indigo H	Organ and tissue preservation, cryopreservation and reconditioning Full Details Shadab Abadpour, Norway Organ-on-chip platform to model metabolic crosstalk between islets and liver Shadab Abadpour, Norway Organ-on-chip platform to model metabolic crosstalk between islets and liver Catherine Parmentier, Canada Islet Isolation after Normothermic Ex Vivo Machine Perfusion of 2 Discarded Human Pancreas Allografts: A Proof of Concept Study Catherine Parmentier, Canada Islet Isolation after Normothermic Ex Vivo Machine Perfusion of 2 Discarded Human Pancreas Allografts: A Proof of Concept Study Mohamed A Elzawahry, United Kingdom Oxygenated hypothermic machine perfusion of the pancreas; a porcine circulatory death model to compare a ‘continuous’ and an ‘end-ischaemic’ approach Mohamed A Elzawahry, United Kingdom Oxygenated hypothermic machine perfusion of the pancreas; a porcine circulatory death model to compare a ‘continuous’ and an ‘end-ischaemic’ approach Anil Kharga, United States Utilization of oxygenated Hemopure based University of Wisconsin solution during simulated procurement, back-benching, and graft implantation to minimize ischemic reperfusion injury in a rat liver transplantation simulated on pump Anil Kharga, United States Utilization of oxygenated Hemopure based University of Wisconsin solution during simulated procurement, back-benching, and graft implantation to minimize ischemic reperfusion injury in a rat liver transplantation simulated on pump Antoine Buemi MD, Belgium Exploring preservation modalities in a split human pancreas model to investigate the effect on the islet isolation outcomes. Antoine Buemi MD, Belgium Exploring preservation modalities in a split human pancreas model to investigate the effect on the islet isolation outcomes. William E Scott III, United Kingdom Generation of optimally-sized primary human pancreatic microtissues through single cell dissociation and a novel suspension microcavity system is associated with resolution of disrupted organelle ultrastructure and reestablishment of cell-cell interactions William E Scott III, United Kingdom Generation of optimally-sized primary human pancreatic microtissues through single cell dissociation and a novel suspension microcavity system is associated with resolution of disrupted organelle ultrastructure and reestablishment of cell-cell interactions Carolin Hermanns, Netherlands A conceptual supportive cell based implant for beta cell replacement therapy Carolin Hermanns, Netherlands A conceptual supportive cell based implant for beta cell replacement therapy Stefan Bencina, Sweden Cryogenic preservation of perinatal stem cells in DMSO-supplemented or DMSO-free GMP-grade conditions Stefan Bencina, Sweden Cryogenic preservation of perinatal stem cells in DMSO-supplemented or DMSO-free GMP-grade conditions Peggy Stock, Germany Human organotypic co-culture model of pleura Peggy Stock, Germany Human organotypic co-culture model of pleura
15:30 - 16:30 \| Networking Event
15:30-16:30	15:30 Terrace	Terrace	Networking Event: Young Investigators Social Gathering Full Details

05:30 - 06:25 | Oral Abstract Sessions

06:00 - 07:30 | Concurrent Sessions

07:30 - 08:00 | Coffee Break and Exhibit Area

08:00 - 09:30 | Oral Abstract Sessions

09:35 - 10:35 | Abstract Sessions

10:35 - 12:00 | Lunch Break and Industry Symposium

12:00 - 13:30 | Concurrents and Abstract Sessions

13:30 - 14:00 | Coffee Break

14:00 - 15:30 | Abstract Sessions / Young Investigator Workshop

15:30 - 16:30 | Networking Event

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